Clinical Expertise 

Vascular Neurosurgery, Interventional Neuroradiology

Intracranial and spinal arteriovenous malformation (AVM), Intracranial and spinal dural arteriovenous fistula (DAVF), Aneurysm, Intracranial and spinal Cavernous Malformation (CM), Hypertensive Intracerebral Hemorrhage (HICH)

Research Interests

Dr. Hong’s research is centered on the mechanisms and treatment of vascular malformations of central nervous system. His work contributed significantly to understanding the natural history and the treatment outcome of spinal arteriovenous malformation, uncovered genetic and molecular mechanism of somatic mutation on brain arteriovenous malformation and cavernous malformation, developed animal model and found candidate medication for these diseases. He has published 21 articles as first/corresponding author in peer-reviewed journals, highlighted by 5 in Brain, 2 in Angiogenesis, 1 in JAMA Neurology and 1 in AJHG. He is funded by 9 grants, including the National Natural Science Foundation of China and the Beijing Municipal Science and Technology Commission, among others.

His current research focuses on the mechanism of brain bleeding caused by brain vascular malformations, employing a bedside-bench-bedside approach, and dedicated to developing medication treatment for these life-altering events.

a. Teaching:

School of Medicine, Capital Medical University

Graduate School, Capital Medical University

International School, Capital Medical University

b. Mentoring:

Residents/Post-doctoral fellows:

Dr. Yongjie Ma, Dr. Jiaxing Yu, Dr. Jian Ren, Dr. Chendan Jiang, Dr. Nan Jiang

Ph.D. students: 

Zhengsong Li, Yeqing Ren, Shiju Zhang, An Tian, Ziwei Cui, Chi Ma

Master’s students:

Yuan Zhou, Haohan Lu, Daochao Wang, Xiaosheng Meng, Ruoru Wu, Menghao Zhang, Hao Yu, Ziyang Zhang

c. Laboratory Personnel

Shikun Zhang, Ph.D. (Senior Research Associate)

Jing Chen,Ph.D. (Senior Research Associate)

Grant support 

Current

Agency: Natural Science Foundation of China

Title: Distinguished Young Scholars

Role: Principal Investigator

Dates: 1/1/2025-12/31/2029

Amount: RMB 4,000,000

Grant number: 82425020

Agency: Natural Science Foundation of China

Title: Somatic Mutation-Mediated Mural Cell Defects in Hemorrhage of     

Central Nervous System Vascular Malformations

Role: Principal Investigator

Dates: 1/1/2024-12/31/2028

Amount: RMB 2,200,000

Grant number: 82330038

Agency: Natural Science Foundation of China

Title: Genetic Mechanism of Vascular Malformations

Role: Principal Investigator 

Dates: 1/1/2022 – 12/31/2024 

Amount: RMB 2,000,000

Grant number: 82122020

Agency: Capital Medical University

Title: Development of New Therapy of Cerebral Vascular Malformation

Role: Principal Investigator

Dates: 1/1/2022-12/31/2025

Amount: RMB 2,000,000

Grant number: 1822922

Past

Agency: Natural Science Foundation of China

Title: RASAL2 in Regulating the Pathogenesis of Cerebral and Spinal 

Arteriovenous Malformation

Role: Principal Investigator

Dates: 1/1/2020 – 12/31/2023

Amount: RMB 550,000

Grant number:81971104

Agency: Beijing Municipal Science and Technology Commission

Title: Molecular Imaging of Cerebral Vascular Diseases

Role: Principal Investigator

Dates: 3/1/2020 – 3/30/2024

Amount: RMB 1,350,000

Grant number: Z201100005520024

Background

Dr. Hong earned his M.D. from Peking Union Medical College, Beijing, China. After completing a neurosurgery residency program and a neurointerventional fellowship at Xuanwu Hospital, Beijing, China, he became an attending neurovascular surgeon in the Department of Neurosurgery in 2017. Dr. Hong also completed a research fellowship at Toronto Western Hospital. He is currently a full professor of neurosurgery at Capital Medical University in Beijing, China. 

Active in both neurosurgery and interventional neuroradiology, Dr. Hong is one of four neurosurgeons in China to have awarded the Distinguished Young Scholars of Natural Science Foundation of China for his research on CNS vascular malformation. He serves as Secretary-General of Chinese Federation of Interventional and Therapeutic Neuroradiology (CFITN). He was nominated as associate editor for JNIS recently and a reviewer for JNS, JNIS, Clinical Neuroradiology, AJNR, etc.

Education

2002 — 2010 M.D., Peking Union Medical College, Beijing

Residencies

2010 — 2015 Residency of Neurosurgery, Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing

Fellowships 

2015-2017

Clinical Fellowship in Endovascular Neurosurgery, Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing

Certifications 

Certificated Neurosurgeon of Beijing Municipal Health Commission

Awards and honors 

2024   Distinguished Young Scholars, The National Science Fund of China

2023   Beijing Youth Medal (30 young scholars under 45 years’ old per year)

2022   Beijing Outstanding Physician Award

2022   NEUROSURGERY Cerebrovascular paper of the Year

2020   Outstanding Teaching Award of Capital Medical University

2018   Outstanding Teaching Award of Xuanwu Hospital

Professional Memberships 

COMMITTEE RESPONSIBILITIES: 

National

2024-present Secretary-General, Chinese Federation of Interventional and Therapeutic Neuroradiology

2022-present Secretary-General, Education Committee of neurosurgery, Ministry of Health, P.R. CHINA

2018-2023 Youth Committee, Chinese Neurosurgical Society 

2019-2023 Vice President of youth committee, Chinese Stroke Association

Regional

2023-present Vice-President, Beijing Association of Interventional and Therapeutic Neuroradiology

Other

Scientific Meetings Organized: 2017-present Co-President, Chinese Annual Conference on Brain and Spinal Vascular Malformation

Research & Publications 

ARTICLES AS FIRST/CORRESPONDING AUTHOR IN PEER-REVIEWED JOURNALS

1. Hong T#, Yan Y#, Li J#, Radovanovic I, Ma X, Shao YW, Yu J, Ma Y, Zhang P, Ling F, Huang S, Zhang H* and Wang Y*. High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations. Brain. 2019;142:23-34.

2. Hong T#, Xiao X#, Ren J#, Cui B, Zong Y, Zou J, Kou Z, Jiang N, Meng G, Zeng G, Shan Y, Wu H, Chen Z, Liang J, Xiao X, Tang J, Wei Y, Ye M, Sun L, Li G, Hu P, Hui R, Zhang H* and Wang Y*. Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations. Brain. 2021;144:2648-2658.

3. Yu JX#, He C#, Ye M#, Li GL, Bian LS, Yang F, Zhai XD, Ling F, Zhang HQ* and Hong T*. The efficacy and deficiency of contemporary treatment for spinal cord arteriovenous shunts. Brain. 2021;144:3381-3391.

4. Yu JX#, Hong T#, Krings T, He C, Ye M, Sun LY, Zhai XD, Xiang SS, Ma YJ, Bian LS, Ren J, Tao PY, Li JW, Yang F, Li GL, Ling F and Zhang HQ*. Natural history of spinal cord arteriovenous shunts: an observational study. Brain. 2019;142:2265-2275.

5. Ren J#, Huang Y#, Ren Y#, Tu T, Qiu B, Ai D, Bi Z, Bai X, Li F, Li JL, Chen XJ, Feng Z, Guo Z, Lei J, Tian A, Cui Z, Lindner V, Adams RH, Wang Y, Zhao F, Körbelin J, Sun W, Wang Y, Zhang H, Hong T* and Ge WP*. Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations. Brain. 2023;146:3634-3647.

6. Ren J#, Cui Z#, Jiang C#, Wang L, Guan Y, Ren Y, Zhang S, Tu T, Yu J, Li Y, Duan W, Guan J, Wang K, Zhang H, Xing D, Kahn ML, Zhang H* and Hong T*. GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas. Am J Hum Genet. 2024;111:1370-1382.

7. Tu T, Zhang S, Li J, Jiang C, Ren J, Zhang S, Meng X, Peng H, Xing D, Zhang H*, Hong T* and Yu J*. Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss. Angiogenesis. 2024;28:1-15.

8. Tu T#, Yu J#, Jiang C#, Zhang S, Li J, Ren J, Zhang S, Zhou Y, Cui Z, Lu H, Meng X, Wang Z, Xing D, Zhang H* and Hong T*. Somatic Braf(V600E) mutation in the cerebral endothelium induces brain arteriovenous malformations. Angiogenesis. 2024;27:441-460.

9. Ren J#, Xiao X#, Li R#, Lv C, Zhang Y, Wang L, Hong T*, Zhang H* and Wang Y*. Single-cell sequencing reveals that endothelial cells, EndMT cells and mural cells contribute to the pathogenesis of cavernous malformations. Exp Mol Med. 2023;55:628-642.

10. Ren J, Wei Y and Hong T*. Combined Cranial Intraosseous and Cerebral Cavernous Malformations With Pathogenic CCM1 Germline Sequence Variations. JAMA Neurol. 2021;78:247-248.

11. Lu HH#, Li ZS#, Li JW, Li GL, He C, Ye M, Hu P, Sun LY, Ma YJ, Ren J, Ling F, Zhang HQ, Yu JX and Hong T*. The natural course, treatment outcomes, and long-term prognosis of cervical spinal cord arteriovenous shunts. J Neurosurg. 2024;141:1212-1224.

12. Yu J#, Zhang S#, Bian L#, He C, Ye M, Li G, Hu P, Sun L, Ling F, Zhang H* and Hong T*. Clinical features and outcomes of perimedullary arteriovenous fistulas: comparison between micro- and macro-type lesions. J Neurointerv Surg. 2023;15:821-827.

13. Ren J#, Jiang N#, Bian L#, Dmytriw AA, Zeng G, He C, Sun L, Li X, Ma Y, Yu J, Li G, Ye M, Hu P, Li J, Yang F, Li Q, Ling F, Zhang H* and Hong T*. Natural History of Spinal Cord Cavernous Malformations: A Multicenter Cohort Study. Neurosurgery. 2022;90:390-398.

14. Feng Y#, Yu J#, Xu J#, He C, Bian L, Li G, Ye M, Hu P, Sun L, Jiang N, Ling F, Hong T* and Zhang H*. Natural History and Clinical Outcomes of Paravertebral Arteriovenous Shunts. Stroke. 2021;52:3873-3882.

15. Ren J#, Hong T#, Zeng G, He C, Li X, Ma Y, Yu J, Ling F and Zhang H*. Characteristics and Long-Term Outcome of 20 Children With Intramedullary Spinal Cord Cavernous Malformations. Neurosurgery. 2020;86:817-824.

16. He Y#, Hong T#, Wang M#, Jiao L#, Ge Y, Haacke EM, Li T* and Hongqi Z*. Prevention and control of COVID-19 in neurointerventional surgery: expert consensus from the Chinese Federation of Interventional and Therapeutic Neuroradiology (CFITN) and the International Society for Neurovascular Disease (ISNVD). J Neurointerv Surg. 2020;12:658-663.

17. Ren J#, Hong T#, He C, Li X, Ma Y, Yu J, Ling F and Zhang H*. Surgical approaches and long-term outcomes of intramedullary spinal cord cavernous malformations: a single-center consecutive series of 219 patients. J Neurosurg Spine. 2019;31:123-132.

18. Hong T, Park JE, Ling F, terBrugge KG, Tymianski M, Zhang HQ* and Krings T*. Comparison of 3 Different Types of Spinal Arteriovenous Shunts below the Conus in Clinical Presentation, Radiologic Findings, and Outcomes. AJNR Am J Neuroradiol. 2017;38:403-409.

19. Ren J#, Hong T#, He C, Sun L, Li X, Ma Y, Yu J, Ling F and Zhang H*. Coexistence of Intracranial and Spinal Cord Cavernous Malformations Predict Aggressive Clinical Presentation. Front Neurol. 2019;10:618.

20. Hong T#, Yu JX#, Liu W, Bian LS, Yang F, Ma YJ, Ling F and Zhang HQ*. Filum Terminale Arteriovenous Fistulas with Multiple Shunt Points: A Report of Two Exceptional Cases. World Neurosurg. 2018;118:235-239.

21. Yu JX#, Hong T#, Ma YJ, Ling F and Zhang HQ*. A New Type of Spinal Epidural Arteriovenous Fistulas Causes Spinal Epidural Hemorrhage: An Analysis of Five Cases and Natural History Consideration. World Neurosurg. 2017;103:371-379.