Research Interests

Filled the gap in the natural history of spinal arteriovenous malformation(AVM) and proposed a new strategy for early surgical intervention; Demonstrated that somatic mutations within the KRAS/BRAF pathway are the critical genetic mechanism of AVM, providing new therapeutic targets; First revealed that MAP3K3 and PIK3CA somatic mutations are the critical genetic mechanism of sporadic cavernous malformations(CM), supporting the molecular classification of CM.

Background

Dr. Tao Hong was born in Nanjing City, Jiangsu Province, PRC. He obtained his M.D. degree at Peking Union Medical College (PUMC) and joined  neurosurgery residency program and endovascular fellow program at Xuanwu hospital. He became an attending neurosurgeon in 2017. He focused on the microsurgical and endovascular treatment of hemorrhagic neurovascular diseases. His research interest was vascular malformation of central nervous system. He conducted a series of research from clinical questions to biomedical sciences, dedicating to improving the clinical outcomes of vascular malformation. He demonstrated the genetic mechanisms of AVMs and CMs and published 11 peer-reviewed papers in high impact journals including BRAIN and JAMA Neurology. He is married and has a daughter.

Education

2002—2010 Peking Union Medical College

Residencies

2010—2017 Residency of Neurosurgery, Xuanwu Hospital, Capital Medical University

Fellowships

Visting Scholar in Interventional Neuroradiology Department of Methodist Hospital (Prof. M. Mawad), Neurosurgical Department of Arkansa Medical University (Prof. G. Yasargil, Prof. Al Melfty), Interventional Neuroradiology Department in New York (Prof. A. Bernstein)

2015 Visting Scholar in Neuroradiology Department of Toronto Western Hospital (Prof. Timo Krings)

Certifications

Physician’s practice license

Professional Memberships

Member, Chinese Federation of Interventional Clinical Neurosciences (CFITN)

Research & Publications

Published Papers

1. Tao Hong#; Yupeng Yan#; Jingwei Li#; Ivan Radovanovic; Xiangyuan Ma; Yang W. Shao; Jiaxing Yu; Yongjie Ma; Peng Zhang; Feng Ling; Shuchen Huang; Hongqi Zhang*; Yibo Wang*; High prevalence of KRAS/BRAF somatic mutations in brain and spinal cord arteriovenous malformations., BRAIN, 2018, 142(1): 23-34.

2. Tao Hong#; Xiao Xiao#; Jian Ren#; Bing Cui; Yuru Zong; Jian Zou; Zqi Kou; Nan Jiang; Guolu Meng; Gao Zeng; Yongzhi Shan; Hao Wu; Zan Chen; Jiantao Liang; Xinru Xiao; Jie Tang; Yukui Wei; Ming Ye; Liyong Sun; Guilin Li; Peng Hu; Rutai Hui; Hongqi Zhang*; Yibo Wang*; Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations, BRAIN, 2021, Mar 17;awab117(Online ahead): doi: 10.1093/brain/awab117.

3. Jia-Xing Yu#; Tao Hong#*; Timo Krings; Chuan He; Ming Ye; Li-Yong Sun; Xiao-Dong Zhai; Si-Shi Xiang; Yong-Jie Ma; Li-Song Bian; Jian Ren; Peng-Yu Tao; Jing-Wei Li; Fan Yang; Gui-Lin Li; Feng Ling; Hong-Qi Zhang*; Natural history of spinal cord arteriovenous shunts: an observational study , BRAIN, 2019, 142 (8): 2265-2275.

4. Jian Ren; Yukui Wei; Tao Hong*; Combined Cranial Intraosseous and Cerebral Cavernous Malformations With Pathogenic CCM1 Germline Sequence Variations., JAMA Neurology, 2020, 78(2): 247-248.

5. Tao Hong; J.E. Park; Feng Ling; K.G. terBrugge; M. Tymianski; Hongqi Zhang*; Timo Krings*; Comparison of 3 Different Types of Spinal Arteriovenous Shunts below the Conus in Clinical Presentation, 

Research Founds

1. Natural Science Foundation of China with grants (81701151, 81971104)

2. Beijing Municipal Science and Technology Commission with grants (Z201100005520024)

3. Beijing Municipal Administration of Hospitals with grants (QML20190802)

4. Beijing Municipal Education Commission with grants (CIT&TCD201904095)