Research Interest

Tumorigenesis and treatment of pituitary adenoma, craniopharyngioma and chordoma

Background

Dr. Liu, Xiaohai was born in Xinghua City, Jiangsu Province, and he successfully received his MD and Ph.D degree at Peking Union Medical College (PUMC) and Dalian Medical University. From 2009.07 to 2013.03, Dr. Liu completed his resident training in the neurosurgery department of PUMC Hospital. He finished has postdoc training between 2013.03 and 2014.11 in Cedar-Sinai Medical Center under the supervision of Dr. Shlomo Melmed. In 2019.06 he started to work in the Neurosurgery Department of Xuanwu Hospital. Dr. Liu is focused on diagnosis and treatment of brain tumors, especially on pituitary neuroendocrine tumors, craniopharyngioma and clival chordoma.

Education

2002—2009 M.D., Dalian Medical University

2009—2012 Ph.D., Neurosurgery, Peking Union Medical College Hospital

2013—2015 Postdoc., Cedars-Sinai Medical Center

Residencies

2009—2013 Residency of Neurosurgery, Peking Union Medical College Hospital

2016—2019 Specialist training of Neurosurgery in Peking Union Medical College Hospital and Xuanwu Hospital, Capital Medical University

Fellowship

Postdoc training between 2013.03 and 2014.11 in Cedar-Sinai Medical Center under the supervision of Dr. Shlomo Melmed.

Certifications

2008: Physician’s practice license

2015: University lecturer qualification

Research & Publications

Published Papers

1、Liu X, et al. Expression of EGFR in pituitary corticotroph adenoma and its relationship with tumor behavior. Front Endocrinol (Lausanne). 2019

2. Liu X，et al. ErbB Receptor-Driven Prolactinomas Respond to Targeted Lapatinib Treatment in Female Transgenic Mice ENDOCRINOLOGY, 2015

3. Liu X. et al. Pituitary Adenoma or Pituitary Neuroendocrine Tumor: A Narrative Review of Controversy and Perspective. Translational Cancer Research, 2021

4. Liu X, et al. Differential Expression of Folate Receptor Alpha in Pituitary Adenomas and Its Relationship to Tumor Behavior, NEUROSURGERY, 2012 5. Liu X, et al. Diagnosis and treatment of refractory pituitary adenomas: a narrative review. Gland Surgery. 2021

6. Liu X. et al. IgG4-Related Inflammatory Pseudotumor Involving the Clivus: A Case Report and Literature Review. Front Endocrinol (Lausanne). 2021

7. Liu X, et al. Combination treatment with bromocriptine and metformin in patients with bromocriptine-resistant prolactinomas: a pilot study. World Neurosurg, 2018.

8. Liu X, et al. Expression of MMP-9, PTTG, HMGA2, and Ki-67 in ACTH-secreting pituitary tumors and their association with tumor recurrence. World Neurosurg, 2018. 

9. Araki Takako, Liu Xiaohai, et al. Kameda H; Tone Y; Fukuoka H; Tone M; Melmed S, EGFR Induces E2F1-Mediated Corticotroph Tumorigenesis., J Endocr Soc., 2017 

10. Liu, X, et al. Antiproliferative, Antiinvasive, and Proapoptotic Activity of Folate Receptor alpha-Targeted Liposomal Doxorubicin in Nonfunctional Pituitary Adenoma Cells , ENDOCRINOLOGY, 2013 

Research Founds

2016-2018 The National Natural Science Foundation of China (81501192)

2018-2020 Special Research Project for Capital Health Development (2018-4-4018)