Research Interests

Preoperative evaluation and surgical treatment of refractory epilepsy；epileptic brain network in refractory epilepsy；molecular mechanism of epilepsy network；multimodal image research；neural circuits research.

Background

Prof. Dr. Zhao, Guoguang was born in Beijing and completed his primary to senior high school studies. From 1984.09 to 2009.07, he completed undergraduate to doctoral studies at Capital Medical University and obtained his M.D. and Ph.D. degree. In 1989.08, Professor Zhao entered the neurosurgery department of Xuanwu Hospital. From 1998 to 2004, Professor Zhao served as deputy director of the Department of Functional Neurosurgery, Xuanwu Hospital Capital Medical University. In 2016.05, he started to be the president of Xuanwu Hospital. In 2021.06, and began to be the director of the epilepsy centre of Xuanwu Hospital. His team focus on preoperative evaluation and treatment of intractable epilepsy, and he has won several national, provincial, and municipal awards. He is married and has a daughter.

Education

Bachelor, Beijing Medical University（1988-1993）

M.A. Neurosurgery, Institute of Gerontology, Ministry of Health（1996-1999）

M.D., Ph.D. Neurosurgery, Peking Union Medical College（2000-2003）

Residencies

Residency and Attending surgeon of Neurosurgery，Xuanwu Hospital, Capital Medical University（1989-1998）

Deputy director of the Department of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University（1998-2004）

Professor of Neurosurgery，Xuanwu Hospital, Capital Medical University（2005-2021）

Fellowships

2003.08-2004.9 Visiting Scholar in Epilepsy Surgery Center, Niguarda Hospital, Milan, Italy.

Certifications

Physician’s practice license

Certificate of resident standardized training of Surgery (Neurosurgery) Phase I

University lecturer qualification

Awards & honors

1. The third national famous doctor in 2019

2. Outstanding scientific, technological and managerial talents in Beijing in 2019

3. Special government allowance of the State Council of the people's Republic of China in 2019

4. Hospital science and technology innovation award of China Hospital Association in 2011

5. Hospital science and technology innovation award of China Hospital Association in 2019

6. The third China Quality Award in 2018

7. Beijing Science and Technology Progress Award in 1996

8. First prize of Beijing Science and Technology Progress Award in 2021

Professional Memberships

Director of National Medical Center for Neurological Disorder

Director of National Geriatric Clinical Research center

Chairman of Expert Steering Committee of National Neurosurgical Robot Application Demonstration project

Vice President of Chinese Congress of Neurological Surgeons (CCNS)

Chairman of Commission on SEEG and Brain Mapping of China Association Against Epilepsy (CAAE)

Standing Committee of the International Society of Minimally Invasive Neurosurgery (ISMINs)

Permanent member of committee of China Association Against Epilepsy (CAAE)

Chairman of Health Promotion and Education Branch of Chinese Preventive Medicine Association

Vice Chairman of the first professional committee of Brain Function Research and Transformation of Chinese Research Hospital Association

Vice president of China Stroke Association

Director of Epilepsy center of Capital Medical University

Vice Chairman of Pediatric Neurology Association of Beijing Doctor Association

Deputy editor in chief of Chinese Journal of Clinicians (Electronic Edition)

Principle investigator of Institute of Epilepsy, Beijing Institute of Major Brain Diseases

Editorial board member of International Neuroscience Journal

Director of Brain Injury Evaluation and Quality Control center of National Health Commission

Research & Publications

Published Papers

1. Comparison between simultaneously acquired arterial spin labeling and 18 F-FDG PET in mesial temporal lobe epilepsy assisted by a PET/MR system and SEEG. Wang Y, An Y, Fan X, Lu J, Ren L, Wei P, Cui B, Du J, Lu C, Wang D, Zhang H, Shan Y*, Zhao G*. Neuroimage Clin. 2018 Jun 7;19:824-830.

2. Electroclinical characteristics of seizures arising from the precuneus based on stereoelectroencephalography (SEEG). Yang Y, Wang H, Zhou W, Qian T, Sun W*, Zhao G*. BMC Neurol. 2018 Aug 13;18(1):110.

3. The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial. Tang Y*, Xing Y, He Y, Li F, Yang J,Liu Q, Li F, Teipel S J, Zhao G*, Jia J*. Alzheimers Dement 2019 May ;15(5):605-614.

4. Optimized stereoelectroencephalography -guided radiofrequency thermocoagulation for mesial temporal lobe epilepsy with hippocampal sclerosis. Fan X, Shan Y, Lu C, An Y, Wang Y, Du J, Wang D, Wei P, Fisher RS, Wang Y, Ren L*, Zhao G*. Seizure. 2019 Oct;71:304-311.

5. Automatic labeling of the fanning and curving shape of Meyer's loop for epilepsy surgery: an atlas extracted from high-definition fiber tractography. Shan Y, Wang Z, Fan X, Zhang H, Ren L, Wei P*; Zhao G*. BMC Neurol. 2019 Nov 28;19(1):302.

6. Optimized stereoelectroencephalography-guided radiofrequency thermocoagulation in the treatment of patients with focal epilepsy. Wang D, Wei P, Shan Y, Ren L*, Wang Y*, Zhao G*. Ann. Trans. Med. 2020 Jan;8(1):15.

7. Electrophysiological properties and seizure networks in hypothalamic hamartoma epilepsies. Wang D, Shan Y, Bartolomei F, Kahane P, An Y, Li M, Zhang H, Fan X, Ou S, Yang Y, Wei P, Lu C, Wang Y, Du J, Ren L*, Wang Y*, Zhao G*. Ann Clin.Neurol. 2020 May;7(5):653-666.

8. Stereo-crossed ablation guided by stereoelectroencephalography for epilepsy: comprehensive coagulations via a network of multi-electrodes. Wei P, Fan X, Wang Y, Lu C, Ou S, Meng F, Li M, Zhang H, Chen S, An Y, Yang Y, Ren L, Shan Y*, Zhao G*. Ther Adv Neurol 2020 Jun 9; 13:1756286420928657.

9. Glucose Metabolism Characteristics of Extra-Hypothalamic Cortex in Patients With Hypothalamic Hamartomas (HH) Undergoing Epilepsy Evaluation: A Retrospective Study of 16 Cases. Yang Y, Wei P, Meng F, An Y, Fan X, Wang Y, Wang D, Ren L, Shan Y*, Zhao G*.Front Neurol. 2021 Jan 14;11:587622

10. Delineating the Decussating Dentato-rubro-thalamic Tract and Its Connections in Humans Using Diffusion Spectrum Imaging Techniques. Ou S, Wei P, Fan X, Wang Y, Meng F, Li M, Shan Y*, Zhao G*. Cerebellum. 2021 May 29.

Book/Book Chapters

1.《Integrated PET / MR operation manual》 2019

2.《Evaluation and surgical treatment of MRI negative epilepsy》 2017

Research Founds

1. Artificial intelligence-based investigation of intrinsic network features and molecular mechanisms in the forms of epileptogenic and non-epileptogenic networks among epilepsy, Founded by Critical Project of National Natural Science Foundation of China, 82030037

2. Mechanical investigation of the interhemispherical propagation of epileptic discharge using quantified connection of corpus callosum, Founded by General Project of National Natural Science Foundation of China, 81871009

3. Development of integrated whole body positron emission / magnetic resonance imaging equipment (PET / MR) - advanced clinical application of PET / MR in nervous system diseases，Founded by Ministry of Science and Technology，2016YFC0103909

4. Capital characteristics multimodal brain function fusion technology and stereotactic electroencephalogram guided radiofrequency thermocoagulation for minimally invasive treatment of drug refractory epilepsy，Founded by Beijing Municipal Commission of Science and Technology，Z161100000516008

5. Clinical promotion and application demonstration of domestic vagus nerve stimulator，Founded by Beijing Municipal Commission of Science and Technology，Z161100000516230

Clinical Trials 

1. SEEG Guided RF-TC v.s. ATL for mTLE With HS (STARTS)

2. Rehabilitative BCI in Acute Ischemic Stroke

3. Atlas of Intracranial Recordings on Cortical Responses After Functional tACS (AIRCRAFT)

4. Training With Brain-machine Interfaces, Visuo-tactile Feedback and Assisted Locomotion for Patients With Chronic Complete Paraplegia

5. Safety and Effects Evaluation of Dentate Nucleus Stimulation in Patients With Post-stroke Paresis (SEEDS)

6. Fornix and NbM as Targets of Stimulation In Alzheimer’s Disease (FANTASIA)