Clinical Expertise 

Stereotactic and Functional neurosurgery, Neuromodulation

Deep Brain Stimulation(DBS), Spinal Cord Stimulation, Radiofrequency ablation of nuclei，Closed-loop neuromodulation, Parkinson's disease, essential tremor, torsion dystonia, hereditary dystonia disorder, cerebral palsy, hereditary spastic paraplegia，anxiety disorder, depression, obsessive-compulsive disorder

Research Interests

DBS surgery of Parkinson's disease, spinal cord stimulation in the treatment of Multisystem atrophy, Multimodal data collection and analysis in evaluation and treatment of PD and anxiety disorder, nanoparticles mediated neuromodulation  

Background

Prof. Dr. Zhang, Yuqing was born in Beijing, and completed his primary to senior high school studies in Beijing, China. He successfully completed undergraduate to doctoral studies at Capital Medical University in 1993 and obtained his M.D. and Ph.D. degree. He entered the Neurosurgery Department of Xuanwu Hospital in 1993.07 and meanwhile started his neurosurgical training. From 1993.07 to 1998.05, Professor Zhang completed his stereotactic and functional neurosurgery training, and he started to be the Attending Doctor of the Functional Neurosurgery Department of Xuanwu Hospital in 1998.05. Since 2013, he served as the Chief Physician of the Functional Neurosurgery Center of Xuanwu Hospital. His team focuses on the diagnosis, treatment, and cutting-edge research of Parkinson's disease and movement disorders. So far, they have assisted 26 hospitals in China in establishing Deep Brain Stimulation centers for movement disorders. He has personally completed over 3000 DBS procedures for Parkinson's disease and led research projects involving neuroimaging, neurophysiology, MR guided focused ultrasound (Mrgfus), brain computer interface, and nanoparticles mediated neuromodulation.

Education

1988 — 1993 Bachelor, Capital Medical University

2000 — 2003 M.A. Neurosurgery, Capital Medical University

2003 — 2006 M.D., Ph.D. Neurosurgery, Capital Medical University

Residencies

1993 — 1998 Residency of Neurosurgery in Xuanwu Hospital, Capital Medical University 

Fellowships

2007: MDS Travel Grant to participate in the 11th International Congress of Parkinson’s Disease and Movement Disorders, (June 3-7, 2007 in Istanbul, Turkey).

2009-2010: Visiting Scholar on PD&DBS in the University of Florida Health Science Center (Prof. Foote), Vanderbilt University Hospital, and Cleveland Clinical Foundation (Prof. Rezai), OH.

2016: Project Reach-PD

Visting fellow in Research on the industry-sponsored studies investigating the application of local field potential to guide Closed-loop DBS implant，Minneapolis, MN.

Certifications

1993 Certificated Neurosurgeon of Xuanwu Hospital, Beijing Municipal Health Commission

2004 Associate chief physician，assistant professor，Beijing Municipal Health Commission

2013 Chief physician of Neurosurgery，Beijing Municipal Health Commission

2024 Professor of Neurosurgery，Capital Medical University

Awards and honors

1. Major Contributions to “Clinical center of excellence” National Parkinson Foundation, Inc., Miami Florida.1999. 

2. Best Paper at the 1st Asian and Oceanic Parkinson's Disease and Movement Disorders Congress in Singapore, 2007.

3. Major Contributions to “The Global Top Center for DBS Therapy”, jointly granted by the Capital Medical University Xuanwu Hospital and Medtronic, Inc.,2009. 

4. Annual Good Doctor of China Doctor Online,2022.

5.“Graduate Supervisor Awards” granted by Xuanwu Hospital and Capital Medical University,2024. 

Professional Memberships

1. Vice Chairman of the Neuroregulation and Brain Computer Interaction Committee of the Beijing Medical Association. 2024-2027

2. Chairman of the Neuroregulation Committee of Beijing Medical Technology Development Association. 2023-2028

3. Chairman of the Brain Network modulation and Medical Engineering Committee of the Beijing Neuroscience Society. 2024-2027

4. Executive Director of Beijing Neurodegenerative Disease Association. 2024-2027

Research & Publications

Publications

1. Wang KL, Li JP, Shan YZ, Zhao GG, Ma JH, Ramirez-Zamora A, Zhang YQ*. Letter of response to “concerns about efficacy of deep brain stimulation (DBS) in centromedian-parafascicular thalamic complex for rapid onset dystonia-parkinsonism (DYT12-ATP1A3)” Brain Stimulation. (2024) 493–495.

2. Wang KL, Li JP, Shan YZ, Zhao GG, Ma JH, Ramirez-Zamora A, Zhang YQ*. Centromedian-parafascicular complex deep brain stimulation improves motor symptoms in rapid onset Dystonia-Parkinsonism (DYT12-ATP1A3). Brain Stimul. 2023. Epub 20230825. doi: 10.1016/j.brs.2023.08.021. PubMed PMID: 37634624.

3. Zhang WJ, Li JP, Huang S, Tian X, Meng Z, Zhang X, Wang Y, Du T, Zhang YQ*. Application-Based Early Interventions of Hardware-Related Infection After Invasive Neuromodulation Prevent Implant Removal. World Neurosurg. 2022;168:74-8. Epub 20220929. doi: 10.1016/j.wneu.2022.09.100. PubMed PMID: 36184044.

4. Jiping Li, Shanshan Mei, XIAOHUA ZHANG, Yunpeng Wang, Xiaofei Jia, Jinlong Liu, Erhe Xu, Wei Mao, Yuqing Zhang*. Combined therapy of bilateral subthalamic nucleus-deep brain stimulation and spinal cord stimulation significantly improves motor function in a patient with multiple system atrophy with predominant parkinsonism. Frontiers in Neuroscience. 2022;26(4)

5. Tianbin Song, Jiping Li, Shanshan Mei, Xiaofei Jia, Hongwei Yang, Yongquan Ye, Jianmin Yuan, Yuqing Zhang, * Jie Lu*. Nigral iron deposition is associated with levodopa-induced dyskinesia in Parkinson’s Disease.Front Neurosci.2021;15:647168.

6. Jiping Li, Shanshan Mei, Xiaofei Jia, Yuqing Zhang. * Evaluation of the direct effect of STN-DBS on levodopa-induced on-dyskinesia in Parkinson's disease. Front Neurol. 2021;12:595741.

7. Sun F, Zhang X, Dong S, Zhang Y, Li J, Wang Y, Zhu J.Effectiveness of Low-Frequency Pallidal Deep Brain Stimulation at 65 Hz in Tourette Syndrome.Neuromodulation. 2021 May 17. doi: 10.1111/ner.13456. Online ahead of print.

8. Wei J, Zou Z, Li J, Zhang YQ*. Gamma Oscillations and Coherence Are Weaker in the Dorsomedial Subregion of STN in Parkinson’s Disease. Front. Neurol. 2021;12:710206. doi: 10.3389/fneur.2021.710206.

9. Li J, Zhang W, Mei S, Qiao L, Wang Y, Zhang X, Li J, Hu Y, Jia X, Zhang YQ*. Prevention and Treatment of Hardware-Related Infections in Deep Brain Stimulation Surgeries: A Retrospective and Historical Controlled Study. Front Hum Neurosci, 2021;15:707816. doi: 10.3389/fnhum.2021.707816.

Research

20230801，ClinicalTrials.gov ID: NCT05971030

Official Tital: Clinical exploratory research of medial Prefrontal Cortex combined with dorsolateral prefrontal cortex electrical stimulation in the treatment of Alzheimer’s Disease (CBS- m/dlPFC-AD)

20201203，ClinicalTrials.gov ID: NCT04683861

Official Title: Spinal Cord Stimulation Therapy for Freezing of Gait in Patients With Advanced Parkinson's Disease and Parkinsonism-Plus Syndrome

20211101，ClinicalTrials.gov ID: NCT04617873

Official Title: Deep Brain Stimulation and Spinal Cord Stimulation Therapy Improve Motor Function in Multiple System Atrophy With Predominant Parkinsonism: a Multicenter, Prospective, Open Label Clinical Trial

20211116，ClinicalTrials.gov ID: NCT05196178

Official Title: Effects of Spinal Cord Stimulation Therapy on Motor Function and Gait in Patients With Pure Hereditary Spastic Paraplegias